Table 1. Sociodemographic characteristics of the All of Us Research Program among participants who completed lifestyle survey and shared their EHR data.

Prevalence (%) and 95% Confidence Interval (95% CI) of opioids use and OUD in the All of Us Research Program among groups of gender, age, race/ethnicity, country of origin, and region of residence.

		Survey Data b				Electronic Health Records (EHR) b
	All of Us Survey-EHR Cohort a	Street Opioids Use		Nonmedical Use of Rx Opioids		Rx Opioid received in the past 3 months	OUD Diagnosis in the past 3 months
		Lifetime	Past 3 months	Lifetime	Past 3 months
	n = 214,206	n = 9,504	n = 145	n = 18,699	n = 505	n = 29,659	n = 2,602
	n (%)	% (95% CI)	% (95% CI)	% (95% CI)	% (95% CI)	% (95% CI)	% (95% CI)
Gender
Women	130,538 (60.94)	2.61 (2.53, 2.70)	0.04 (0.03, 0.05)	7.91 (7.76, 8.06)	0.27 (0.25, 0.30)	13.85 (13.66, 14.04)	0.87 (0.82, 0.92)
Men	79,548 (37.14)	7.31 (7.13, 7.50)	0.11 (0.09, 0.14)	10.05 (9.84, 10.26)	0.17 (0.14, 0.20)	13.82 (13.58, 14.06)	1.73 (1.64, 1.83)
Age (Years)
18–39	59,115 (27.60)	5.50 (5.32, 5.69)	---	10.77 (10.52, 11.02)	0.13 (0.10, 0.16)	12.02 (11.76, 12.28)	1.51 (1.41, 1.61)
40–49	31,385 (14.65)	5.83 (5.57, 6.09)	0.10 (0.07, 0.15)	11.25 (10.91, 11.61)	0.30 (0.25, 0.37)	13.81 (13.43, 14.20)	1.81 (1.67, 1.96)
50–59	44,313 (20.69)	4.89 (4.69, 5.10)	0.14 (0.11, 0.18)	8.94 (8.68, 9.21)	0.38 (0.32, 0.44)	15.13 (14.79, 15.46)	1.46 (1.35, 1.57)
60–69	45,469 (21.23)	4.08 (3.90, 4.26)	0.08 (0.06, 0.11)	7.33 (7.09, 7.57)	0.22 (0.18, 0.27)	15.06 (14.73, 15.39)	0.92 (0.84, 1.02)
≥ 70	33,924 (15.84)	1.19 (1.08, 1.31)	---	4.44 (4.23, 4.67)	0.20 (0.16, 0.26)	13.77 (13.40, 14.14)	0.23 (0.18, 0.29)
Race/Ethnicity
White	110,152 (51.42)	4.81 (4.69, 4.94)	---	10.97 (10.78, 11.15)	0.18 (0.16, 0.21)	14.81 (14.60, 15.02)	1.31 (1.24, 1.38)
Black or African American	45,151 (21.08)	4.62 (4.43, 4.82)	0.21 (0.18, 0.26)	6.03 (5.81, 6.25)	0.34 (0.29, 0.40)	12.26 (11.96, 12.57)	1.04 (0.95, 1.14)
Hispanic or Latino	42,014 (19.61)	3.53 (3.36, 3.71)	0.06 (0.04, 0.09)	6.27 (6.04, 6.50)	0.26 (0.22, 0.32)	13.72 (13.39, 14.06)	1.18 (1.08, 1.28)
Asian	5,944 (2.77)	0.82 (0.62, 1.10)	---	4.07 (3.59, 4.61)	---	8.06 (7.39, 8.79)	---
Country of origin
US born	178,534 (83.35)	5.03 (4.93, 5.13)	0.08 (0.06, 0.09)	9.79 (9.66, 9.93)	0.24 (0.22, 0.26)	14.44 (14.28, 14.61)	1.36 (1.3, 1.41)
Not US born	33,460 (15.62)	1.14 (1.03, 1.26)	---	2.99 (2.82, 3.18)	0.21 (0.16, 0.26)	10.64 (10.31, 10.97)	0.36 (0.30, 0.44)
Region of residence c
West	56,326 (26.30)	5.17 (4.99, 5.35)	---	11.01 (10.75, 11.27)	0.30 (0.25, 0.35)	21.17 (20.83, 21.51)	1.12 (1.03, 1.21)
South	39,409 (18.40)	3.08 (2.91, 3.25)	---	7.44 (7.18, 7.70)	0.26 (0.22, 0.32)	7.89 (7.63, 8.16)	0.51 (0.44, 0.59)
Midwest	43,146 (20.14)	4.26 (4.07, 4.45)	0.20 (0.16, 0.25)	7.33 (7.09, 7.58)	0.17 (0.14, 0.22)	11.92 (11.62, 12.23)	0.74 (0.66, 0.82)
Northeast	65,264 (30.47)	4.92 (4.76, 5.09)	0.05 (0.04, 0.08)	8.69 (8.47, 8.91)	0.22 (0.19, 0.26)	12.69 (12.43, 12.94)	2.09 (1.98, 2.20)

^a Percentages may not sum to 100 because of missing data

^b The prevalence with the number of patients <20 was not shown in this table according to the policy of All of Us Data and Statistics Dissemination

^c West: Alaska, Arizona, California, Colorado, Hawaii, Idaho, Montana, Nevada, New Mexico, Oregon, Utah, Washington, Wyoming; South: Alabama, Arkansas, Delaware, Florida, Georgia, Kentucky, Louisiana, Maryland, Mississippi, North Carolina, Oklahoma, South Carolina, Tennessee, Texas, Virginia, West Virginia, Washington, D.C.; Midwest: Illinois, Indiana, Iowa, Kansas, Michigan, Minnesota, Missouri, Nebraska, North Dakota, Ohio, South Dakota, Wisconsin; Northeast: Connecticut, Maine, Massachusetts, New Hampshire, New Jersey, New York, Pennsylvania, Rhode Island, Vermont