Abstract
Presumptive embolic chorioretinal Torulopsis glabrata infection is described in a patient who had received prolonged intravenous antibiotic therapy. The ocular findings are compared and contrasted with embolic lesions due to Candida albicans. The patient was treated for 6 weeks with intravenous miconazole. During this time there was shrinkage of the ocular lesions, some improvement in vision and abolition of fungaemia. Improvement in tests of immune function during treatment suggests that an early immunological deficit was secondary to the infection. Intravenous miconazole is a relatively nontoxic alternative to amphotericin and deserves further evaluation in the treatment of ocular mycosis.
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- ASHER R. Munchausen's syndrome. Lancet. 1951 Feb 10;1(6650):339–341. doi: 10.1016/s0140-6736(51)92313-6. [DOI] [PubMed] [Google Scholar]
- Aisner J., Schimpff S. C., Sutherland J. C., Young V. M., Wiernik P. H. Torulopsis glabrata infections in patients with cancer. Increasing incidence and relationship to colonization. Am J Med. 1976 Jul;61(1):23–28. doi: 10.1016/0002-9343(76)90026-7. [DOI] [PubMed] [Google Scholar]
- Bennet J. E. Flucytosine. Ann Intern Med. 1977 Mar;86(3):319–321. doi: 10.7326/0003-4819-86-3-319. [DOI] [PubMed] [Google Scholar]
- Edwards J. E., Jr, Foos R. Y., Montgomerie J. Z., Guze L. B. Ocular manifestations of Candida septicemia: review of seventy-six cases of hematogenous Candida endophthalmitis. Medicine (Baltimore) 1974 Jan;53(1):47–75. doi: 10.1097/00005792-197401000-00002. [DOI] [PubMed] [Google Scholar]
- Elliott J. H., O'Day D. M., Gutow G. S., Podgorski S. F., Akrabawi P. Mycotic endophthalmitis in drug abusers. Am J Ophthalmol. 1979 Jul;88(1):66–72. doi: 10.1016/0002-9394(79)90757-8. [DOI] [PubMed] [Google Scholar]
- Fleming K. O. Candida albicans abscess of retina. Can J Ophthalmol. 1972 Apr;7(2):132–135. [PubMed] [Google Scholar]
- Francois M. M., Turut P., Guilbert M. F. Les candidoses rétiniennes. Arch Ophtalmol Rev Gen Ophtalmol. 1974 Dec;34(12):863–877. [PubMed] [Google Scholar]
- GRIMLEY P. M., WRIGHT L. D., Jr, JENNINGS A. E. TORULOPSIS GLABRATA INFECTION IN MAN. Am J Clin Pathol. 1965 Mar;43:216–223. doi: 10.1093/ajcp/43.3.216. [DOI] [PubMed] [Google Scholar]
- Getnick R. A., Rodrigues M. M. Endogenous fungal endophthalmitis in a drug addict. Am J Ophthalmol. 1974 May;77(5):680–683. doi: 10.1016/0002-9394(74)90531-5. [DOI] [PubMed] [Google Scholar]
- Griffin J. R., Pettit T. H., Fishman L. S., Foos R. Y. Blood-borne Candida endophthalmitis. A clinical and pathologic study of 21 cases. Arch Ophthalmol. 1973 Jun;89(6):450–456. doi: 10.1001/archopht.1973.01000040452002. [DOI] [PubMed] [Google Scholar]
- Jones B. R. Principles in the management of oculomycosis. XXXI Edward Jackson memorial lecture. Am J Ophthalmol. 1975 May;79(5):719–751. doi: 10.1016/0002-9394(75)90730-8. [DOI] [PubMed] [Google Scholar]
- Larsen P. A., Lindstrom R. L., Doughman D. J. Torulopsis glabrata endophthalmitis after keratoplasty with an organ-cultured cornea. Arch Ophthalmol. 1978 Jun;96(6):1019–1022. doi: 10.1001/archopht.1978.03910050543010. [DOI] [PubMed] [Google Scholar]
- Lees A. W., Rao S. S., Garret J. A., Boot P. A. Endocarditis due to Torulopsis glabrata. Lancet. 1971 May 8;1(7706):943–944. doi: 10.1016/s0140-6736(71)91445-0. [DOI] [PubMed] [Google Scholar]
- Marks M. I., Langston C., Eickhoff T. C. Torulopsis glabrata--an opportunistic pathogen in man. N Engl J Med. 1970 Nov 19;283(21):1131–1135. doi: 10.1056/NEJM197011192832103. [DOI] [PubMed] [Google Scholar]
- Meyers B. R., Lieberman T. W., Ferry A. P. Candida endophthalmitis complicating candidemia. Ann Intern Med. 1973 Nov;79(5):647–653. doi: 10.7326/0003-4819-79-5-647. [DOI] [PubMed] [Google Scholar]
- Robertson D. M., Riley F. C., Hermans P. E. Endogenous Candida oculomycosis. Report of two patients treated with flucytosine. Arch Ophthalmol. 1974 Jan;91(1):33–38. doi: 10.1001/archopht.1974.03900060037009. [DOI] [PubMed] [Google Scholar]
- Rodrigues R. J., Shinya H., Wolff W. I., Puttlitz D. Torulopsis glabrata fungemia during prolonged intravenous alimentation therapy. N Engl J Med. 1971 Mar 11;284(10):540–541. doi: 10.1056/NEJM197103112841009. [DOI] [PubMed] [Google Scholar]
- STENDERUP A., PEDERSEN G. T. Yeasts of human origin. Acta Pathol Microbiol Scand. 1962;54:462–472. doi: 10.1111/j.1699-0463.1962.tb05088.x. [DOI] [PubMed] [Google Scholar]
- Steer P. L., Marks M. I., Klite P. D., Eickhoff T. C. 5-fluorocytosine: an oral antifungal compound. A report on clinical and laboratory experience. Ann Intern Med. 1972 Jan;76(1):15–22. doi: 10.7326/0003-4819-76-1-15. [DOI] [PubMed] [Google Scholar]
- Stern G. A., Fetkenhour C. L., O'Grady R. B. Intravitreal amphotericin B treatment of Candida endophthamitis. Arch Ophthalmol. 1977 Jan;95(1):89–93. doi: 10.1001/archopht.1977.04450010089008. [DOI] [PubMed] [Google Scholar]
- Stobo J. D., Paul S., Van Scoy R. E., Hermans P. E. Suppressor thymus-derived lymphocytes in fungal infection. J Clin Invest. 1976 Feb;57(2):319–328. doi: 10.1172/JCI108283. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Symoens J. Clinical and experimental evidence on miconazole for the treatment of systemic mycoses: a review. Proc R Soc Med. 1977;70 (Suppl 1):4–8. [PMC free article] [PubMed] [Google Scholar]
- Weinstein A. J., Johnson E. H., Moellering R. C., Jr Candida endophthalmitis. A complication of candidemia. Arch Intern Med. 1973 Nov;132(5):749–752. [PubMed] [Google Scholar]