Table 2. Meta-analysis results of association between TNF-α-308G/A polymorphism and OSA.

Contrast model		Subjects (cases/controls)	Studies,n	OR (95%CI)	P *	I2(%)
Total studies
allele model	A vs. G	5190/5158	14	1.87 (1.47, 2.38)	0	69.10
dominant model	AA/AG vs. GG	2595/2579	14	1.88(1.48, 2.39)	0	59.50
recessive model	AA vs. AG/GG	2269/2360	11	2.83 (2.00, 4.00)	0	15.00
homozygous model	AA vs. GG	2269/2360	11	3.30 (2.32, 4.68)	0	20.80
heterozygous model	AG vs. GG	2595/2579	14	1.67 (1.36, 2.06)	0	38.80
Subgroup analysis
Caucasians
allele model	A vs. G	1220/1958	5	1.40(1.03, 1.90)	0.033	53.50
dominant model	AA/AG vs. GG	610/979	5	1.48 (1.03, 2.13)	0.035	56.30
recessive model	AA vs. AG/GG	439/860	3	1.77 (1.00, 3.13)	0.048	0.00
homozygous model	AA vs. GG	439/860	3	2.19 (1.23, 3.90)	0.008	0.00
heterozygous model	AG vs. GG	610/979	5	1.46 (1.04, 2.06)	0.029	48.10
Asians
allele model	A vs. G	3970/3200	9	2.30 (1.62, 3.26)	0	72.60
dominant model	AA/AG vs. GG	1985/1600	9	2.23 (1.59, 3.14)	0	62.80
recessive model	AA vs. AG/GG	1830/1500	8	3.51 (2.06, 5.98)	0	11.00
homozygous model	AA vs. GG	1830/1500	8	4.22 (2.32, 7.67)	0	23.10
heterozygous model	AG vs. GG	1985/1600	9	1.86 (1.40, 2.47)	0	39.60
Subgroup analysis
HB
allele model	A vs. G	3798/3084	9	2.37 (1.68, 3.32)	0	70.40
dominant model	AA/AG vs. GG	1899/1542	9	2.30 (1.66, 3.20)	0	58.70
recessive model	AA vs. AG/GG	1830/1500	8	3.51 (2.06, 5.98)	0	11.00
homozygous model	AA vs. GG	1830/1500	8	4.22 (2.32, 7.67)	0	23.10
heterozygous model	AG vs. GG	1899/1542	9	1.89 (1.45, 2.47)	0	31.40
PB
allele model	A vs. G	1392/2074	5	1.35 (0.98, 1.85)	0.068	58.40
dominant model	AA/AG vs. GG	696/1037	5	1.41 (0.97, 2.06)	0.074	61.40
recessive model	AA vs. AG/GG	439/860	3	1.77 (1.00, 3.13)	0.048	0.00
homozygous model	AA vs. GG	439/860	3	2.19 (1.23, 3.90)	0.008	0.00
heterozygous model	AG vs. GG	696/1037	5	1.40 (0.98, 2.00)	0.066	54.50

Abbreviation

HB: hospital-based

PB: population-based

Note:P^*:P value for pooled OR.