Table 4.
Basic Clinical Characteristics Between MACEs Groups and Non-MACEs Groups in Patients with STEMI
| Basic Clinical Characteristics | MACEs Group, n=85 | Non-MACEs Group, n=131 | P -valueb |
|---|---|---|---|
| Demographics | |||
| Age, years | 64.00(55.00,69.50) | 61.00(50.00,69.00) | 0.108 |
| Male gender, n (%) | 69(81.18) | 112(85.50) | 0.400 |
| Smoking, n (%) | 59(69.41) | 85(64.89) | 0.491 |
| Hypertension, n (%) | 55(64.71) | 77(58.78) | 0.383 |
| Diabetes mellitus, n (%) | 21(24.71) | 19(14.50) | 0.059 |
| BMI (kg/m2) | 24.09(22.49,25.28) | 24.45(23.03,25.95) | 0.068 |
| Killip class ≥ II, n (%) | 39(45.88) | 28(21.37) | <0.001 |
| Time from pain-to-balloon (h) | 3.0(2.5,5.0) | 3.0(2.0,5.0) | 0.421 |
| In-hospital day | 12(10,15.5) | 11(10,13) | 0.026 |
| Prior medications | |||
| Beta-blocker, n (%) | 66(77.65) | 113(86.26) | 0.101 |
| ACEI/ARBs, n (%) | 50(58.82) | 92(70.23) | 0.084 |
| CCB, n (%) | 6(7.06) | 12(9.16) | 0.585 |
| Laboratory parameters | |||
| CK-MB peak (ng/dL) | 128.20(52.42,297.29) | 83.00(27.80,274.33) | 0.101 |
| Troponin I peak (ng/dL) | 13.549(7.099,40.425) | 11.070(2.360,25.200) | 0.035 |
| Hemoglobin (g/L) | 139(125.5,148.5) | 140(129,148) | 0.788 |
| Albumin (g/L) | 36.768±4.588 | 37.102±3.482 | 0.573a |
| Total cholesterol (mmol/L) | 4.490(3.940,5.135) | 4.500(3.830,5.110) | 0.779 |
| Triglyceride (mmol/L) | 1.520(1.115,2.120) | 1.520(1.000,2.020) | 0.862 |
| HDL cholesterol (mmol/L) | 1.090(0.930,1.180) | 1.090(0.930,1.250) | 0.599 |
| LDL cholesterol (mmol/L) | 2.640(2.265,3.035) | 2.640(2.160,3.070) | 0.438 |
| C-reactive protein (mg/L) | 12.70(4.38,39.66) | 7.60(3.20,13.90) | 0.003 |
| Serum creatinine (μmol/L) | 72.00(62.00,95.50) | 72.00(63.00,83.00) | 0.437 |
| Fibrinogen (g/L) | 3.350(2.850,3.880) | 2.880(2.480,3.610) | 0.001 |
| D-dimer (mg/L) | 0.520(0.295,0.985) | 0.370(0.220,0.560) | <0.001 |
| Lipoprotein (a) (mg/L) | 125.00(82.60,286.20) | 86.90(44.00,172.00) | 0.001 |
| Uric acid (umol/L) | 392.00(281.50,487.50) | 360.00(292.00,428.00) | 0.127 |
| Carotid artery calcification | 35(41.18) | 66(50.38) | 0.185 |
| LVEF on admission (%) | 58.00(53.50,60.00) | 60.00(58.00,61.00) | <0.001 |
| LVDd (mm) | 46.00(44.00,49.00) | 46.00(42.00,49.00) | 0.166 |
| Localization of MI, n (%) | |||
| Left main coronary artery, n (%) | 5(5.88) | 3(2.29) | 0.319 |
| Left anterior descending artery, n (%) | 39(45.88) | 71(54.20) | 0.232 |
| Left circumflex artery, n (%) | 14(16.47) | 17(12.98) | 0.474 |
| Right coronary artery, n (%) | 27(31.76) | 40(30.53) | 0.849 |
| Angiographic characteristics | |||
| Number of diseased artery ≥ 2, n (%) | 68(80.00) | 75(57.25) | 0.001 |
| Mean stent diameter (mm) | 3.000(2.750,3.375) | 3.000(2.750,3.250) | 0.517 |
| Total stent length (mm) | 36.00(29.00,57.50) | 33.00(24.00,47.00) | 0.009 |
| No-reflow, n (%) | 26(30.59) | 16(12.21) | 0.001 |
| Gensini score | 80.00(52.00,93.00) | 52.00(38.00,80.00) | <0.001 |
| Inflammation indicators | |||
| Admission SII value | 845.80(493.30,1550.26) | 596.67(282.98,1046.38) | 0.002 |
| 12hours after PCI SII value | 1499.82(901.97,2202.86) | 915.40(604.86,1468.45) | <0.001 |
| Discharge SII value | 695.82(420.00,1031.74) | 526.72(395.42,679.09) | <0.001 |
| Admission SIRI value | 2.724(1.335,5.050) | 1.623(0.870,2.888) | <0.001 |
| 12hours after PCI SIRI value | 6.115(4.293,10.646) | 3.295(2.243,5.269) | <0.001 |
| Discharge SIRI value | 1.610(1.048,3.053) | 1.272(0.868,1.806) | <0.001 |
| Admission PIV value | 507.48(299.20,1046.60) | 314.22(148.77,612.48) | <0.001 |
| 12hours after PCI PIV value | 1186.14(700.38,2305.88) | 645.89(372.84,1098.48) | <0.001 |
| Discharge PIV value | 381.54(179.27,781.58) | 260.32(86.66,352.78) | <0.001 |
| SII change between Admission and 12hours after PCI | 450.78(−51.65,1250.11) | 312.51(−246.02,954.29) | 0.115 |
| SII change between Discharge and 12hours after PCI | −646.36(−1333.45,-212.46) | −388.47(−933.40,-77.82) | 0.033 |
| SII change between Discharge and Admission | −16.413(−610.544,308.691) | −131.54(−437.92,196.99) | 0.400 |
| SIRI change between Admission and 12hours after PCI | 3.758(1.177,6.271) | 1.317(0.254,2.974) | <0.001 |
| SIRI change between Discharge and 12hours after PCI | −4.236(−7.644,-2.156) | −2.124(−3.675,-1.004) | <0.001 |
| SIRI change between Discharge and Admission | −0.277(−2.626,0.596) | −0.384(−1.696,0.355) | 0.939 |
| PIV change between Admission and 12hours after PCI | 628.16(232.20,1360.62) | 204.42(17.64,613.76) | <0.001 |
| PIV change between Discharge and 12hours after PCI | −652.11(−1907.21,-298.96) | −370.94(−764.42,-100.30) | <0.001 |
| PIV change between Discharge and Admission | −15.604(−489.620,198.766) | −80.02(−275.51,73.73) | 0.459 |
Notes: aUnpaired Student’s t test. bMann–Whitney U-test and Chi-square test/Fisher’s exact test.
Abbreviations: MACEs, major adverse cardiovascular events; BMI, body mass index; ACEI/ARBs, angiotensinogen converting enzyme inhibitor/angiotensinogen receptor blockers; CCB, calcium channel blocker; CK-MB, creatine kinase, myocardial; HDL cholesterol, high-density lipoprotein cholesterol; LDL cholesterol, low-density lipoprotein cholesterol; LVEF, left ventricular ejection fraction; LVDd, Left ventricular end diastolic diameter; SII, systemic immune-inflammation index; SIRI, systemic inflammation response index; PIV, Pan-Immune-Inflammation Value; PCI, percutaneous coronary intervention.