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. 2023 Mar 23;108(9):2154–2175. doi: 10.1210/clinem/dgad134

Figure 5.

Figure 5.

Simulated 24-hour hydrocortisone PK/PD hormone profiles in a prepubertal child with 21OHD. Simulated 24-hour cortisol, 17OHP, and A4 concentrations in a prepubertal child with 21OHD based on 3 times a day hydrocortisone dosing regimen using an integrated PK/PD model (46). The target range for cortisol, 17OHP, and A4 is shaded in gray. Dotted lines represent age- and sex-specific normal ranges. Abbreviations: 17OHP, 17-hydroxyprogesterone; 21OHD, 21-hydroxylase deficiency; A4, androstenedione; PK/PD, pharmacokinetic-pharmacodynamic.