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. 2023 Mar 23;108(9):2154–2175. doi: 10.1210/clinem/dgad134

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© The Author(s) 2023. Published by Oxford University Press on behalf of the Endocrine Society.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (https://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 7. — Wide variability of adrenal steroid concentrations within a 2-hour time frame after the morning hydrocortisone dose in a representative child with 21OHD. Observed cortisol, 17OHP, and A4 concentrations over 6 hours. Shaded area depicts a 2-hour time window, 1 to 3 hours post morning 6 mg hydrocortisone dose. Concentration levels of each adrenal steroid showed a > 60% change within the 2-hour time frame. Child's regular total daily hydrocortisone dose was 12 mg/m²/day. Abbreviations: 17OHP, 17-hydroxyprogesterone; 21OHD, 21-hydroxylase deficiency; A4, androstenedione.