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. 2023 Aug 4;14:1172360. doi: 10.3389/fphar.2023.1172360

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Copyright © 2023 Wang, Long, Hu and Guo.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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GPS enhanced intestinal integrity in HFD and STZ-induced diabetic mice (A) Representative images of immunohistochemical staining performed to determine ZO-1 and occludin expression levels in the ileum of the diabetic mice, n = 4. The magnification of all images is at × 200 (B) Statistical analysis of occluding protein expression, n = 4 (C) Statistical analysis of ZO-1 protein expression, n = 4 (D) Representative protein bands of ZO-1 and occludin, n = 6 (E) Relative optical density of ZO-1 levels, n = 6 (F) Relative optical density of occludin levels, n = 6. Data are presented as mean ± SEM. ^# p < 0.05; ^## p < 0.01 vs. Nor group; *p < 0.05; **p < 0.01 vs. Mod group.