Table 3.
Table gives actual values of all neuroanatomy data. All values are stated as mean ± SEM. * denotes significant difference (P ≤ 0.05) between wild-type control, APPNL-F/NL-F and APPNL-FMAPTHTAUvalues.
| Region | Age | Parameter | Wild-type |
APPNL-F/NL-F |
APPNL-F/MAPTHTAU |
|||
|---|---|---|---|---|---|---|---|---|
| Mean ± SEM | n | Mean ± SEM | n | Mean ± SEM | n | |||
| LEC | (11–16 months) | Aβ integrated density | 9.32 ± 2.78 | 5 | 18.11 ± 1.97 | 6 | 40.18 ± 1.93* | 5 |
| Hyper ptau integrated density | 2.39 ± 0.40 | 9 | 14.80 ± 3.40* | 7 | 50.77 ± 4.60* | 5 | ||
| GFAP optical density | 4.93 ± 0.58 | 5 | 8.56 ± 2.23 | 5 | 10.23 ± 1.43 | 5 | ||
| CD68 optical density | 1.71 ± 0.04 | 5 | 3.01 ± 0.59* | 6 | 2.92 ± 0.59 | 6 | ||
| (18–22 months) | Aβ integrated density | 9.36 ± 2.81 | 8 | 22.23 ± 6.35* | 6 | 22.45 ± 3.07* | 7 | |
| Hyper ptau integrated density | 2.17 ± 0.86 | 7 | 13.58 ± 2.51* | 6 | 32.86 ± 5.03 * | 7 | ||
| GFAP optical density | 4.34 ± 0.60 | 6 | 7.19 ± 1.69 | 5 | 6.12 ± 0.60 | 6 | ||
| CD68 optical density | 1.50 ± 0.29 | 5 | 2.34 ± 0.33 | 6 | 2.47 ± 0.18 | 7 | ||
| CA1 | (11–16 months) | Aβ integrated density | 6.66 ± 1.37 | 5 | 34.64 ± 3.82* | 7 | 45.17 ± 3.17* | 5 |
| Hyper ptau integrated density | 3.74 ± 0.78 | 9 | 11.54 ± 2.05 | 7 | 51.67 ± 8.16* | 5 | ||
| GFAP optical density | 10.21 ± 1.18 | 5 | 12.15 ± 3.39 | 6 | 11.91 ± 2.26 | 5 | ||
| CD68 optical density | 1.52 ± 0.17 | 6 | 2.65 ± 0.42 | 6 | 3.53 ± 0.45* | 5 | ||
| (18–22 months) | Aβ integrated density | 11.39 ± 3.41 | 8 | 29.75 ± 8.64* | 5 | 40.20 ± 3.73* | 8 | |
| Hyper ptau integrated density | 2.73 ± 0.86 | 7 | 20.98 ± 5.64* | 6 | 26.34 ± 4.44* | 8 | ||
| GFAP optical density | 7.72 ± 1.18 | 5 | 9.81 ± 2.53 | 5 | 12.49 ± 2.99 | 5 | ||
| CD68 optical density | 1.84 ± 0.12 | 5 | 2.53 ± 0.51 | 6 | 3.15 ± 0.43* | 7 | ||
| PRS | (11–16 months) | Aβ integrated density | 8.54 ± 2.81 | 5 | 11.87 ± 3.53 | 5 | 16.44 ± 3.46 | 5 |
| Hyper ptau integrated density | 4.52 ± 1.18 | 10 | 2.30 ± 0.36 | 7 | 8.20 ± 1.97 | 5 | ||
| GFAP optical density | 5.29 ± 1.05 | 5 | 3.37 ± 3.39 | 6 | 4.61 ± 0.83 | 4 | ||
| CD68 optical density | 1.86 ± 0.08 | 6 | 1.85 ± 0.08 | 6 | 1.71 ± 0.07 | 5 | ||
| (18–22 months) | Aβ integrated density | 6.79 ± 1.91 | 8 | 9.91 ± 2.86 | 5 | 6.28 ± 3.13 | 7 | |
| Hyper ptau integrated density | 2.47 ± 0.82 | 8 | 4.12 ± 1.44 | 5 | 3.88 ± 1.23 | 7 | ||
| GFAP optical density | 3.83 ± 1.07 | 6 | 4.39 ± 1.54 | 5 | 2.45 ± 0.35 | 8 | ||
| CD68 optical density | 1.86 ± 0.12 | 5 | 1.90 ± 0.26 | 5 | 1.67 ± 0.05 | 7 | ||