Fig. 4.

Total serum bilirubin change from baseline at each visit in completers of 12 weeks of treatment. Placebo: N = 12; 3 mg OD: N = 4; 10 mg OD: N = 14; 30 mg OD: N = 5; 30 mg BID: N = 4; 60 mg BID: N = 11 Day 1 was the SoT visit (visit 3). The EoT visit (visit 7) was scheduled after 84 days of treatment ± 4 days. The visits at days 10, 28, and 56 also had a leeway of ± 4 days. ^aBaseline is the last available measurement before the start of treatment (either the measurement taken at visit 3 [labelled ‘Day 1 SoT’ in this figure] or, if that is not available, the measurement taken at visit 1[screening]). BID twice daily, EoT end of treatment, OD once daily, SoT start of treatment