Table 1.
Baseline demographics
| Participants | Placebo n = 31 |
BAY1128688 | Total N = 121 |
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|---|---|---|---|---|---|---|---|
| 3 mg OD n = 11 |
10 mg OD n = 31 |
30 mg OD n = 10 |
30 mg BID n = 11 |
60 mg BID n = 27 |
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| Age at baseline (years) | |||||||
| Mean (SD) | 31.4 (5.7) | 32.5 (9.2) | 32.7 (6.1) | 32.9 (4.9) | 33.5 (5.4) | 31.3 (7.3) | 32.1 (6.4) |
| Race, n (%) | |||||||
| White | 31 (100) | 11 (100) | 30 (96.8) | 10 (100) | 11 (100) | 26 (96.3) | 119 (98.3) |
| Multiple or other | 0 | 0 | 1 (3.2) | 0 | 0 | 1 (3.7) | 2 (1.6) |
| Baseline BMI (kg/m2) | |||||||
| Mean (SD) | 25.1 (4.0) | 23.4 (5.4) | 23.3 (2.5) | 23.2 (4.0) | 24.2 (4.0) | 22.9 (3.5) | 23.8 (3.9) |
| Alcohol use, n (%) | |||||||
| Abstinent | 10 (32.3) | 2 (18.2) | 6 (19.4) | 1 (10.0) | 4 (36.4) | 9 (33.3) | 32 (26.4) |
| Light | 17 (54.8) | 9 (81.8) | 24 (77.4) | 6 (60.0) | 7 (63.6) | 17 (63.0) | 80 (66.1) |
| Moderate | 4 (12.9) | 0 | 1 (3.2) | 3 (30.0) | 0 | 1 (3.7) | 9 (7.4) |
| Tobacco use, n (%) | |||||||
| Never | 16 (51.6) | 8 (72.7) | 20 (64.5) | 4 (40.0) | 10 (90.9) | 14 (51.9) | 72 (59.5) |
| Former | 7 (22.6) | 1 (9.1) | 3 (9.7) | 2 (20.0) | 0 | 3 (11.1) | 16 (13.2) |
| Current | 8 (25.8) | 2 (18.2) | 8 (25.8) | 4 (40.0) | 1 (9.1) | 10 (37.0) | 33 (27.3) |
BID twice daily, BMI body mass index, OD once daily, SD standard deviation