Table 2.

Mitochondrial proteins with statistically significant differences in their abundance in untreated and MNNG-treated WT vs. HtrA2/Omi KO MEF [ANOVA of scaled abundances using 5% FDR and post-hoc Tukey’s HSD test (5%), and additional pairwise comparison of groups by Student’s t test]

Protein accession	Protein description	q value	ANOVA − log10 p value	ANOVA significant?	t test
					WT MNNG/WT	KO MNNG/KO	WT/KO	WT MNNG/ KO MNNG
Q8BGT5	Alanine aminotransferase 2	0.049	3.365	Yes			0.005	0.006
Q9D6S7	Ribosome-recycling factor, mitochondrial	0.053	3.001	Yes			0.006	0.013
P52196	Thiosulfate sulfurtransferase	0.074	2.533	No			0.012	0.017
Q99LD8	N(G),N(G)-dimethylarginine dimethylaminohydrolase 2	0.092	2.337	No			0.025
O35680	28S ribosomal protein S12, mitochondrial	0.122	2.404	No				0.014
P58059	28S ribosomal protein S21, mitochondrial	0.176	2.061	No				0.014
Q8R4N0	Citrate lyase subunit beta-like protein, mitochondrial	0.198	1.696	No				0.017
Q8K411-1	Presequence protease, mitochondrial	0.251	1.557	No				0.035
Q99LY9	NADH dehydrogenase [ubiquinone] iron-sulfur protein 5	0.306	1.247	No				0.037
P02340	Cellular tumor antigen p53	0.805	0.314	No		0.039

Empty cells: differences in the protein abundance between the two sample conditions did not reach statistical significance