| We evaluated the risk of hyponatremia associated with the tramadol/acetaminophen (TA) combination oral pill using hospital data compatible with OMOP–CDM. | |
| Compared with acetaminophen, TA was associated with a higher risk of hyponatremia. | |
| We also observed a higher risk of hyponatremia among users of TA extended-release formulations compared with those using TA immediate-release formulations. |
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