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. 2023 Aug 18;14:5031. doi: 10.1038/s41467-023-40680-5

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — a Echocardiographic analysis of ventricular function and structure at 28 days post-tamoxifen treatment. Percent (%) fractional shortening (FS) and left ventricular internal dimension in end diastole (LVID;d). MCM (n = 8 biologically independent animals), Rab7^f/f (n = 11 biologically independent animals), Rab7^f/f MCM (n = 11 biologically independent animals). b Heart weight to body weight ratio (HW/BW). MCM (n = 8), Rab7^f/f (n = 11 biologically independent animals), Rab7^f/f MCM (n = 11 biologically independent animals). c Hematoxylin and eosin (H&E) and Masson’s Trichrome staining of heart sections. Scale bar = 0.5 mm. d Ultrastructural analysis by transmission electron microscopy at D28 (representative of n = 2 biologically independent samples). e Representative Western blots and quantification of endosomal proteins (Rab7/Gapdh: Rab7^f/f (n = 11 biologically independent animals) Rab7^f/f MCM (n = 11 biologically independent animals); Rab27/Gapdh: Rab7^f/f (n = 12 biologically independent animals), Rab7^f/f MCM (n = 11 biologically independent animals); CD81/Gapdh: Rab7^f/f (n = 10 biologically independent animals), Rab7^f/f MCM (n = 12); Tsg101/Gapdh: Rab7^f/f (n = 11 biologically independent animals), Rab7^f/f MCM (n = 11 biologically independent animals); Arl8b/Gapdh: Rab7^f/f (n = 8 biologically independent animals), Rab7^f/f MCM (n = 7 biologically independent animals)). f Representative Western blots and quantification of autophagy proteins (n = 11 biologically independent animals). Data are mean ± SEM. ns = not significant. P values shown are by ANOVA with Tukey’s post-hoc testing (a) or two-sided Student’s t-test (e, f). Source data are provided as a Source Data file.