Table 1.

Hedgehog signaling pathway target genes

Target gene	Full name of the gene	Function of the gene products
Ptch184	Patched 1	Receptor that initiates signaling pathways, negative feedback regulation
Ptch284	Patched 2	Receptor that initiates signaling pathways
Gli184	Glioma-associated oncogene 1	Direct transcriptional activator, positive feedback regulation
Bmi185	Bmi1 proto-oncogene	Transcriptional repressor regulating the proliferative capacity of cells
Myc86	Myc proto-oncogene	Cell cycle progression, apoptosis and cellular transformation
CycD and CycE87	CyclinD and CyclinE	Cell cycle progression
Fgf489	Fibroblast growth factor 4	Involved in varieties of biological processes including embryonic development, cell growth, morphogenesis, tissue repair and invasion
Hhip88	Hedgehog interacting protein	Involved in varieties of developmental processes including anteroposterior patterns of limbs and regulation of left-right asymmetry in embryonic development
Nkx6.190	NK6 homeobox 1	Required for the development of beta cells
Nkx2.290	NK2 homeobox 2	Involved in the morphogenesis of the central nervous system
Olig290	Oligodendrocyte transcription factor 2	Regulator of ventral neuroectodermal progenitor cell fate
FoxA290	Forkhead box A2	Transcriptional activators that regulate the specificity and differentiation of dopaminergic neurons
Snai191	Snail family transcriptional repressor 1	Critical for mesoderm formation in the developing embryo
Zeb191	Zinc finger E-box binding homeobox 1	Associated with posterior polymorphous corneal dystrophy-3 and late-onset Fuchs endothelial corneal dystrophy
Twist291	Twist family bHLH transcription factor 2	Inhibitors of osteoblast maturation, maintaining the pre-osteoblast phenotype of cells during osteoblast development
Foxc291	Forkhead box C2	Involved in the development of mesenchymal tissues
Pax6, Pax7 and Pax997	Paired box 6, 7 and 9	Involved in the development of neural tissues