TABLE 3.
Studies related to tissue engineering of UCMSCs for IVD regeneration.
References | Scaffolds | Results |
---|---|---|
Leckie et al. (2013) | Fibrin hydrogel | UCMSCs combined with hydrogels were superior to UCMSCs alone and hydrogels alone in terms of imaging performance, biomechanics, cell number and ECM content |
Reppel et al. (2015) | Alginate/hyaluronic acid hydrogel | WJ-MSCs exhibited greater type II collagen synthesis than BM-MSCs at the transcript and protein levels |
Ahn et al. (2015) | Hyaluronic acid | XHA hydrogel scaffold and high expression of TβRI/ALK5 and TβRII facilitate regeneration of IVD by WJ-MSCs |
Li et al. (2017) | Porous chitosan/poly (l-lactic acid) scaffold | Tissue engineered for greater IVD regeneration than blank control and autologous bone |
Choi et al. (2020) | Hyaluronan-methylcellulose hydrogels | Combined injection of WJ-MSCs and HAMC enhanced IVD regeneration through increase in cell survival, attenuation of the activation of iNOS, MMP-13, ADAMTS4 and COX-2, and significant upregulation of ECM. |
UCMSCs, Umbilical Cord Mesenchymal Stem Cells; ECM, extracellular matrix; XHA, Cross-linked hyaluronic acid.