Table 3.
Performance of triage for the detection of CIN3+ among 391 hrHPV+ women (validation set)
| Triage algorithms | Colposcopy referral rates (%) (n/N) | Sensitivity (%) (n/N) 95% CI | Specificity (%) (n/N) 95% CI | PPV (%) (n/N) 95% CI | NPV (%) (n/N) 95% CI | NNC | Compared with TCT(ASCUS+) |
Compared with HPV16/18 or TCT(ASCUS+) |
||
|---|---|---|---|---|---|---|---|---|---|---|
| Relative Sensitivity (95%CI) | Relative specificity (95%CI) | Relative Sensitivity (95%CI) | Relative specificity (95%CI) | |||||||
| TCT(ASCUS+) | 74.42 (291/391) | 85.44 (135/158) 78.75–90.36 | 33.05 (77/233) 27.12–39.54 | 46.39 (135/291) 40.58–52.30 | 77.00 (77/100) 67.31–84.58 | 2.16 | 1 | 1 | – | – |
| HPV16/18 | 41.94 (164/391) | 58.86 (93/158) 50.75–66.53 | 69.53 (162/233) 63.12–75.28 | 56.71 (93/164) 48.75–64.34 | 71.37 (162/227) 64.94–77.06 | 1.76 | 0.69 (0.59–0.80) | 2.10 (1.71–2.59) | – | – |
| ZNF671m | 51.15 (200/391) | 78.48 (124/158) 71.10–84.45 | 67.38 (157/233) 60.90–73.28 | 62.00 (124/200) 54.85–68.68 | 82.20 (157/191) 75.87–87.20 | 1.61 | 0.92 (0.84–1.00) | 2.04 (1.68–2.48) | – | – |
| HPV16/18 or TCT(ASCUS+) | 85.17 (333/391) | 94.94 (150/158) 89.93–97.63 | 21.46 (50/233) 16.48–27.40 | 45.05 (150/333) 39.64–50.57 | 86.21 (50/58) 74.07–93.44 | 2.22 | 1.11 (1.05–1.17) | 0.65 (0.55–0.77) | 1 | 1 |
| HPV16/18 or ZNF671m | 67.26 (263/391) | 90.51 (143/158) 84.56–94.41 | 48.50 (113/233) 41.95–55.10 | 54.37 (143/263) 48.14–60.47 | 88.28 (113/128) 81.11–93.07 | 1.84 | 1.06 (0.98–1.15) | 1.47 (1.17–1.83) | 0.95 (0.90–1.01) | 2.26 (1.78–2.87) |
| ZNF671m or TCT(ASCUS+) | 82.10 (321/391) | 93.04 (147/158) 87.58–96.30 | 25.32 (59/233) 19.97–31.50 | 45.79 (147/321) 40.27–51.42 | 84.29 (59/70) 73.20–91.52 | 2.18 | 1.09 (1.04–1.14) | 0.77 (0.68–0.87) | 0.98 (0.93–1.03) | 1.18 (0.97–1.44) |
| HPV16/18 or ZNF671m or TCT(ASCUS+) | 89.26 (349/391) | 98.10 (155/158) 94.12–99.51 | 16.74 (39/233) 12.31–22.30 | 44.41 (155/349) 39.15–49.80 | 92.86 (39/42) 79.45–98.14 | 2.25 | 1.15 (1.08–1.23) | 0.51 (0.41–0.63) | 1.03 (1.00–1.06) | 0.78 (0.67–0.90) |
m, methylation; PPV, positive predictive values; NPV, positive predictive values; NNC, the number of colposcopies needed for detection per CIN3+ case.