Table 2.
Metabolic characteristics of deletion carriers and BMI-matched controls
| Category | Trait | Deletion carriers | Matched controls | p |
|---|---|---|---|---|
| Adiposity | prevalence of plumper at age 10 (%) | 41.4 | 23.3 | 0.002 |
| Glycemia | prevalence of T2D (%) | 37.9 | 14.4 | <2 × 10−16 |
| age of onset of T2D | 51.1 ± 2.4 | 54.8 ± 0.5 | 1.6 × 10−7 | |
| prevalence of diabetes treatment (%) | 59.1 | 35.8 | 0.033 | |
| number of antidiabetic drugsa | 1.69 ± 0.13 | 1.37 ± 0.04 | 0.022 | |
| glucosea (mmol/L) | 8.39 ± 1.18 | 6.97 ± 0.17 | 0.018 | |
| HbA1ca (mmol/mol) | 53.3 ± 3.9 | 48.7 ± 0.7 | 0.080 | |
| prevalence of diabetes with complications (%) | 31.8 | 25.8 | 0.534 | |
| Renal function | cystatin C (mg/L) | 1.077 ± 0.028 | 0.929 ± 0.003 | 6.0 × 10−14 |
| Inflammation | C-reactive protein (mg/L) | 4.84 ± 0.73 | 3.49 ± 0.09 | 0.015 |
| Serum lipids | total cholesterol (mmol/L) | 5.04 ± 0.14 | 5.62 ± 0.02 | 5.8 × 10−5 |
| triglycerides (mmol/L) | 2.10 ± 0.17 | 1.97 ± 0.02 | 0.926 | |
| Cardiovascular system | prevalence of hypertension (%) | 60.3 | 66.0 | 0.373 |
| diastolic blood pressure (mmHg) | 79.8 ± 1.5 | 84.6 ± 1.9 | 2.8 × 10−4 | |
| prevalence of cardiovascular diseases (%) | 10.3 | 14.7 | 0.357 |
Descriptive statistics reporting the prevalence or mean value (± SE) for key metabolic phenotypes in deletion carriers and BMI-matched controls. Statistical significance of the difference between the two group is reported as a p value. Exact trait definitions, statistical tests, and further inferential statistics are described in Tables S7 and S8.
a
Among people with documented diabetes.