Skip to main content
. 2023 Aug 15;4(8):101153. doi: 10.1016/j.xcrm.2023.101153

Figure 1.

Figure 1

Gut microbes were closely associated with therapeutic failure of azathioprine (AZA) in patients with inflammatory bowel disease

(A) Flow chart of fecal microbiota transplantation (FMT) experiments with feces from patients in remission (R) or patients in non-remission (NR).

(B) Schematic overview of treatments in conventional DSS-induced colitis model. n = 6 for each group.

(C) The alteration of body weight in conventional DSS-induced colitis mouse. n = 6/group, non-parametric Wilcoxon rank-sum test. Data are represented as mean ± SEM.

(D) Gross morphology of the colon was shown in different treatment groups of conventional DSS-induced colitis mice.

(E) Mouse colonic sections were stained by hematoxylin and eosin in conventional DSS-induced colitis mice. Original magnification, ×5 (top row) and ×20 (bottom row).

(F) The histology scores of colonic sections in conventional DSS-induced colitis. n = 6/group, non-parametric Wilcoxon rank-sum test. Data are represented as mean ± SD.

(G) Schematic overview of treatments in conventional TNBS-induced colitis model. n = 6 for each group.

(H) The alteration of body weight in conventional TNBS-induced colitis mouse. n = 6/group, non-parametric Wilcoxon rank-sum test. Data are represented as mean ± SEM.

(I) Gross morphology of the colon was shown in different treatment group of conventional TNBS-induced colitis mice.

(J) Mouse colonic sections were stained by hematoxylin and eosin in conventional TNBS-induced colitis. Original magnification, ×5 (top row) and ×20 (bottom row).

(K) The histology scores of colonic sections in conventional TNBS-induced colitis. n = 6/group, non-parametric Wilcoxon rank-sum test. Data are represented as mean ± SD.

(L) Schematic overview of treatments in germ-free DSS-induced colitis model. n = 6 for each group.

(M) The alteration of body weight in germ-free DSS-induced colitis mouse. n = 6/group, non-parametric Wilcoxon rank-sum test. Data are represented as mean ± SEM.

(N) Gross morphology of the colon was shown in different treatment group of germ-free DSS-induced colitis mice.

(O) Mouse colonic sections were stained by hematoxylin and eosin in germ-free DSS-induced colitis mice. Original magnification, ×5 (top row) and ×20 (bottom row).

(P) The histology scores of colonic sections in germ-free DSS-induced colitis. n = 6/group, non-parametric Wilcoxon rank-sum test. Data are represented as mean ± SD.