Table 1.
Basic differences between migrasomes, retractosomes and exosomes.
| Migrasome | Retractosome | Exosome | |
|---|---|---|---|
| Origin | During migration, migrasomes are formed at the tip or bifurcation of the RFs | Broken-out retraction fibers | Multivesicular body (MVB) |
| Essence | Organelle | Extracellular vesicles | Extracellular vesicles |
| Diameter | 500-3000 nm | 50–250 nm | 30–150 nm |
| Content | EVs, impaired mitochondria, mRNA, miRNA, Protein, and other components are still being explored | Protein and other components are still being explored | DNA, mRNA, miRNA, LncRNA, Protein, Lipid, MHC-1/2 |
| Protein composition | Scarcely any LAMP1 | Scarcely any LAMP1 | The LAMP1 can be marked with the label |
| Markers | TSPAN4, TSPAN7, NDST1, PIGK, CPQ, EOGT, Integrin (α1, α3, α, β1) | PIGK, EOGT, PCCA (Lower enrichment levels compared to the migrasomes) | CD9, CD63, CD81, HSP60, HSP70, HSP90, TSG101 |
| Migration-dependent | Yes | Yes | No |
| ECM-dependent | Yes | Yes | No |