Figure 1.

Digital architecture for automated data transfer as one option of the FINE-REAL study. Data are extracted and harmonized from the EHRs of various PMSs at the study centers using SaniQ software and transferred to the AlcedisTRIAL EDC system. Solid arrows indicate a synchronous request (arrow pointing to the right) or query (arrow pointing to the left); the dashed arrows indicate an asynchronous request or query. EDC: electronic data capture; EHR: electronic health record; PMS: practice management system.