Table 1.
Selected drugs associated with ferroptosis in oncology
| Target | Drug | Tumor type | Effect | References |
|---|---|---|---|---|
| Xc-system | Sulfasalazine | Lymphomas, pancreatic cancer, and lung cancer | Induce | [153, 154] |
| Sorafenib | Hepatocellular and renal cell carcinoma and thyroid cancer | Induce | [155] | |
| Erastin | Cholesterol-reducing reagents | Induce | [156] | |
| TMZ | Gliomas | Inhibit | [157, 158] | |
| GPX4 | β-elemene(Cetuximab) | Colorectal cancer (KRAS-mutant) | Induce | [159] |
| Withaferin A | Breast cancer, osteosarcoma, neuroblastoma treatment | Induce | [134] | |
| Altretamine | Lymphoma, sarcoma, ovarian cancer treatment | Induce | [160] | |
| GSH | Cisplatin | Ovarian cancer, pancreatic cancer, urothelial cancer, lung cancer | Induce | [161, 162] |
| BSO | Melanoma, neuroblastoma | Induce | [163, 164] | |
| Fe | Artesunate | Pancreatic cancer, Burkitt’s Lymphoma | Induce | [165–167] |
| Ironomycin | Pancreatic cancer | Induce | [168] | |
| Neratinib | Breast cancer, CRC | Induce | [167] | |
| Lapatinib | Breast cancer | Induce | [167] | |
| Salinomycin | Various solid tumor types | induce | [87] | |
| CoQ10 | Statins | Cholesterol-reducing reagents | Induce | [116] |
GPX4 Glutathione Peroxidase 4, TMZ Temozolomide, GSH glutathione, BSO Buthionine sulfoximine, CRC colorectalcancer