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. 2023 Aug 19;6:863. doi: 10.1038/s42003-023-05239-6

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — Stimulation of phosphorylation of intracellular Akt (green) and Erk 1/2 (orange) proteins in murine fibroblasts with deleted igf1r gene (R- cells) (a) and in MC3T3-E1 preosteoblasts (b) by human insulin (HI), IGF1, IGF2, big-IGF2(87), big-IGF2(104), and pro-IGF2(156). Data are presented as means ± S.D., relative to the signal in non-stimulated cells. Significant differences between marked values determined using Ordinary one-way ANOVA (Dunnett´s multiple comparisons test), *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001.