Table 2.

Target population

Target population in Geroscience trial	Definition	Potential indications
Subjects at risk of age-related diseases	Age-related diseases: Defined as disease with increased incidence in old age and generated by chronic impairment of the hallmark of aging	Atherosclerosis, cardio-vascular disease, cancer, osteo-arthritis, osteoporosis, type 2 diabetes, hypertension, cataract, Alzheimer’s disease, pre-eclampsia, others
Subjects with accelerated aging-like states	Accelerated aging disease: Genetic disorder that result in accelerated aging-like states	Down syndrome, progeria, Werner syndrome
Subject facing an accelerated aging-like condition	Accelerated aging condition: Clinical condition that results in accelerated phenotypic or biological aging	Immobilization, radiation, chemotherapy, exposure to toxins (tobacco, alcohol…), surgery, cardiopulmonary bypass surgery, hypoxia, prematurity, space flight, others
Subjects at risk of geriatric syndromes	Geriatric syndrome: Group of age-related acute or chronic common health condition that are associated with poor resilience	Delirium, fall, functional limitation, undernutrition, frailty, sarcopenia, cognitive impairment, depression, others
Subjects with (or at risk of) declining Intrinsic capacity (IC)	Intrinsic capacity: Concept that represents the composite of all physical and mental capacities	Older adult with abnormal IC domains (mobility, sensory, mood, cognition, vitality) as defined by WHO