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. 2023 Aug 19;13:13512. doi: 10.1038/s41598-023-40622-7

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Mechanisms of Treg induction by CD34 sorted HUVECs. CD34^high and CD34^low HUVECs were seeded at high confluence and after adhesion, were co-cultured with PBMCs for 4 days (A) or before co-culture, HUVECs and PBMC were pre-treated with an antibody directed against the IL-33R (ST2) to block IL-33 interaction with its receptor (B). Proliferation of Treg (% of CFSE- cells in Treg population) is also shown (A). The % Treg (% CD127^lowCD45RA⁻FoxP3^high in CD4⁺T cells) (B) was evaluated at day 4. PBMC alone (PBMC only) were used as a control. The results are shown as before and after representation and each dot correspond to a single experiment (*p < 0.05, **p < 0.01: two-tailed Wilcoxon test).