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. 2023 Aug 19;21:282. doi: 10.1186/s12951-023-01974-4

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — The electrospinning process for the creation of polymer-free and free-standing acyclovir/cyclodextrin nanofibers, notable for their exceptional histocompatibility and facilitation of drug release in the treatment of viral keratitis. A Chemical structures of (a) HP-βCD, (b) PVP, and (c) acyclovir are presented, (d-e) alongside schematic diagrams demonstrating their interrelationships. B Experimental data confirms the solubility of acyclovir/HP-βCD nanofibers and acyclovir/PVP nanofibers in an artificial saliva environment.

Adapted from Ref. [218] with permission from Elsevier