Skip to main content
. Author manuscript; available in PMC: 2023 Aug 20.
Published in final edited form as: Nat Biotechnol. 2022 Oct 3;40(11):1617–1623. doi: 10.1038/s41587-022-01432-w

Figure 3. Comparing RGN2 and AF2 structure predictions for orphan proteins.

Figure 3.

(A) Stacked bar charts show the relative fractions of secondary structure elements in orphan proteins broken down by these categories: RGN2 outperforms AF2, AF2 outperforms RGN2, and no clear winner. Bar height indicates protein length. (B-D) Alpha helical targets of different lengths (5FKP, 2KWZ, and 6E5N) which contain bends or hydrogen-bonded turns between helical domains tend to be better predicted by RGN2 than AF2.