Table 3.
Subgroup Analysis for Associations Between SII Index and the Prevalence of NAFLD
| SII Index | Q1 | Q2 | Q3 | Q4 | P for Trend | P for Interaction |
|---|---|---|---|---|---|---|
| OR (95% CI) | OR (95% CI) | OR (95% CI) | OR (95% CI) | |||
| Age | 0.129 | |||||
| < 60 | 1.00 | 1.021 (0.566, 1.841) | 0.613 (0.333, 1.130) | 0.910 (0.506, 1.635) | 0.496 | |
| ≥ 60 | 1.00 | 0.779 (0.323, 1.878) | 0.500 (0.202, 1.236) | 2.302 (0.889, 5.959) | 0.214 | |
| Sex | 0.451 | |||||
| Male | 1.00 | 0.919 (0.443, 1.907) | 0.567 (0.245, 1.308) | 1.115 (0.481, 2.585) | 0.882 | |
| Female | 1.00 | 0.873 (0.461, 1.651) | 0.524 (0.281, 0.975)* | 1.050 (0.577, 1.911) | 0.923 | |
| Hypertension | 0.647 | |||||
| No | 1.00 | 0.947 (0.499, 1.798) | 0.587 (0.295, 1.167) | 1.133 (0.583, 2.201) | 0.928 | |
| Yes | 1.00 | 0.885 (0.429, 1.824) | 0.515 (0.255, 1.042) | 0.874 (0.436, 1.752) | 0.445 | |
| DM | 0.217 | |||||
| No | 1.00 | 0.884 (0.528, 1.479) | 0.470 (0.270, 0.817) | 0.918 (0.537, 1.570) | 0.382 | |
| Yes | 1.00 | 1.221 (0.333, 4.480) | 0.858 (0.254, 2.894) | 2.522 (0.779, 8.171) | 0.142 | |
| BMI | 0.490 | |||||
| < 30 kg/m2 | 1.00 | 0.972 (0.529, 1.787) | 0.376 (0.195, 0.728)* | 0.922 (0.492, 1.729) | 0.252 | |
| ≥ 30 kg/m2 | 1.00 | 1.038 (0.464, 2.322) | 0.837 (0.381, 1.840) | 1.333 (0.612, 2.902) | 0.490 |
Notes: *P < 0.01. Analysis was adjusted for age, sex, race/ethnicity, education level, marital status, family poverty income ratio, the complication of hypertension, and diabetes mellitus, smoke status, and drink status, the complication of coronary heart disease, congestive heart failure, angina pectoris, heart attack, and stroke, body mass index, waist circumference, fast glucose, glycosylated hemoglobin, hemoglobin, high-sensitivity C-reactive protein, alanine aminotransferase, aspartate amino transferase, gamma-glutamyl transpeptidase, blood urea nitrogen, uric acid, serum creatinine, estimated glomerular filtration rate, high-density lipoprotein-cholesterol, total cholesterol, triglyceride.
Abbreviations: SII index, systemic immune inflammation index; NAFLD, non-alcoholic fatty liver disease; Q1, 50.000–292.000; Q2, 292.001–423.059; Q3, 423.060–602.735; Q4, 602.736–3250.714; OR, odd ratio; CI, confidence interval.