Table 2.
Drugs used in combination therapy. Chemotherapy drugs with different mechanisms in combination with various active ingredients of herbal medicine were listed
| Drug | Mechanism of action | Combination with |
|---|---|---|
| cisplatin | DNA alkylation | Noscapine (24, 28), Thymoquinone (39, 41), resveratrol (70), Oxymatrine (73), Eugenol (74), Rosmarinic acid (57), Curcumin (75), Gingerol (76) |
| Docetaxel | Microtubule inhibitor | Noscapine (77), Thymoquinone (50) |
| Paclitaxel | Mitosis inhibitor | Noscapine (26), resveratrol (65) |
| Doxorubicin | Topoisomerase II inhibitor | Noscapine (28), Thymoquinone (43, 45), resveratrol (63), Oxymatrine (78), Curcumin (79), Gingerol (80) |
| Gemcitabine | pyrimidine analogs | Eugenol (81) |
| Fluorouracil (5-FU) | Thymidylate synthase inhibitor | Thymoquinone (34), resveratrol (59), Rosmarinic acid (82) |
| Cyclophosphamide | DNA alkylation | Thymoquinone (37) |
| Raloxifene | Estrogen antagonists | Resveratrol (53) |
| Rapamycin | Inhibits Lymphocytes activation | Resveratrol (62) |
| Bevacizumab | Angiogenesis blocker by VEGF inhibition | Oxymatrine (83) |
| Oxaliplatin | Inhibition of DNA synthesis | Oxymatrine (84), Curcumin (85) |
| Dacarbazine | DNA alkylation | Eugenol (86) |
| Mitotane | Adrenal cortex inhibitor | Curcumin (87) |