Figure 2.

Chagas Disease Burden Model. Schematic representation of the compartmental model used to calculate the burden of disease from spatio-temporal predictions of the Force-of-Infection (FoI). The model takes into account the occurrence of co-morbidities, such that individuals in each compartment can have heart disease before becoming infected with Trypanosoma cruzi. For each compartment in the model, the age class-specific prevalence of each stage was calculated along with the mortality caused or not caused by Chagas disease depending on whether the progression was or was not due to T. cruzi infection. Details on the progression rates and compartments used are provided in electronic supplementary material, text S3 and tables S3–S5.