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. 2023 Jun 30;27(2):78–95. doi: 10.20463/pan.2023.0021

Figure 2.

Figure 2.

Skeletal muscle tissue of the human vastus lateralis muscle in the rested state (left) and after intense resistance exercise (right). (A) Electron microscopic picture of skeletal muscle in the rested state showing regular z-disk alignment in undamaged sarcomeres. (B) Electron microscopic picture of human skeletal muscle 24 h after intense RE, exhibiting myofibrillar damage, z-disk streaming, and irregular orientation of fibrils. (C) Fluorescence staining of the z-disk marker FLNC (green) of a human skeletal muscle fiber at rest in the untrained and undamaged state. (D) Fluorescence staining of the z-disk marker FLNC (green) and Xin-repeat binding protein (XIRP1) (red) as a marker of myofibrillar damage in a myofiber 60 min post intense RE. Note that the overlay (orange) clearly shows the abundance of a myofibrillar lesion in which XIRP co-localizes within a strongly damaged area of sarcomeres.