Table 1.
Baseline demographics and features of each MarkVCID Cohort
| Cohort 1 (n=95) | Cohort 2 (n=96) | Cohort 3 (n=97) | Combined Cohort (n=335) | |
|---|---|---|---|---|
| Demographic Characteristics | ||||
| Age in years (SD) | 71.7 (8.2) | 72.5 (6.8) | 71.8 (8.5) | 72.2 (7.8) |
| Sex (% female) | 49.5% | 49.0% | 49.5% | 49.3% |
| Vascular Risk Factors | ||||
| Hypertension (%) | 47.4% | 46.9% | 52.6% | 48.7% |
| Diabetes (%) | 17.9% | 27.1% | 17.5% | 21.5% |
| Hyperlipidemia (%) | 49.5% | 53.1% | 63.9% | 53.7% |
| H/o stroke (%) | 8.4% | 8.3% | 7.2% | 7.8% |
| Plasma Biomarker | ||||
| Median plasma PlGF (pg/mL) [IQR] | 8.71 [6.61 – 10.0] | 8.06 [6.92 – 10.8] | 8.46 [7.10 – 10.1] | 8.31 [6.77 – 10.1] |
| Study Outcome Variables | ||||
| Median CDRg (IQR) | 0 (0 - 0.5) | 0 (0 – 0.5) | 0 (0 – 0.5) | 0 (0 – 0.5) |
| Median CDRsum (IQR) | 0.5 (0 – 1) | 0 (0 - 0.5) | 0 (0 – 1) | 0 (0 – 1) |
| Median Fazekas (IQR) | 3 (1 – 3) | 3 (2 – 3) | 2 (1 – 3) | 3 (2 – 3) |
| Mean LogWMH (IQR) | 0.71 (−0.21 - 1.61) | 1.38 (0.57 - 2.28) | 1.20 (0.08 - 2.29) | 1.12 (0.13 - 2.17) |
| Mean UDS3-EF (IQR) | −0.45 (−1.03 - 0.17) | −0.54 (−1.07 - 0.05) | −0.31 (−0.75 - 0.22) | −0.43 (−0.94 - 0.19) |
CDR – Clinical Dementia Rating scale; IQR – Interquartile range; LogWMH – log-adjusted volumetric white matter hyperintensity measurement; PlGF – placental growth factor; UDS3-EF – Uniform Data Set 3 – Executive Function score