Table 2.

Ordinal logistic regression models of plasma PlGF as a diagnostic VCID biomarker.

Outcome Variable	Cohort 1 (n=89)			Cohort 2 (n=93)			Cohort 3 (n=96)			Combined Cohort (n=322)
Primary	Beta	OR (CI)	p	Beta	OR (CI)	p	Beta	OR (CI)	p	Beta	OR (CI)	p
Imaging Outcome* (Fazekas)	0.095	1.10 (0.93-1.30)	0.27	0.249	1.28 (1.06-1.55)	0.011	0.217	1.24 (1.05-1.47)	0.011	0.147	1.16 (1.07-1.25)	0.0003
Cognitive Outcome* (CDR)	0.162	1.18 (0.99-1.40)	0.068	0.231	1.26 (1.09 - 1.45)	0.001	0.463	1.59 (1.31-1.93)	<0.0001	0.202	1.22 (1.14-1.32)	<0.0001
Secondary
Imaging Outcome** (vWMH)	0.048		1.78e-4	0.057		2.50e-3	0.172		5.93e-5	0.104		5.42e-15
Cognitive Outcome** (UDS3-EF)	−0.022		0.83	−0.052		0.147	−0.049		0.108	−0.030		0.070

^*Age- and sex-adjusted ordinal logistic regression model using unadjusted plasma PlGF values (pg/mL).

^**Age- and sex-adjusted linear regression model using unadjusted plasma PlGF values (pg/mL).

CDR – Cognitive Dementia Rating Scale; vWMH – volumetric white matter hyperintensity imaging; UDS3-EF – Uniform Data Set 3.0 – Executive Function score