Table 4.
Characteristics of the study population by history of uterine leiomyoma
| N (%) or Mean (SD) | Black Participants | White Participants | ||
|---|---|---|---|---|
| N = 2995 | N = 4876 | |||
| Leiomyoma=No | Leiomyoma=Yes | Leiomyoma=No | Leiomyoma=Yes | |
| N = 1700 | N = 1295 | N = 3829 | N = 1047 | |
| Site | ||||
| AACES | 760 (44.7) | 569 (43.9) | N/A | N/A |
| BWHS | 296 (17.4) | 402 (31.0) | N/A | N/A |
| LACOCS | 163 (9.6) | 106 (8.2) | 2283 (59.6) | 663 (63.3) |
| NCOCS | 194 (11.4) | 110 (8.5) | 1326 (34.6) | 340 (32.5) |
| SCCS | 287 (16.9) | 108 (8.3) | 220 (5.8) | 44 (4.2) |
| Case-Control Status | ||||
| Cases | 518 (30.5) | 444 (34.3) | 1504 (39.3) | 488 (46.6) |
| Controls | 1182 (69.5) | 851 (65.7) | 2325 (60.7) | 559 (53.4) |
| Age at Ovarian Cancer Diagnosis or Interview | 54.58±11.86 | 56.07±9.75 | 56.71±11.52 | 59.03±9.55 |
| Histotype * | ||||
| High-Grade Serous | 334 (64.5) | 280 (63.1) | 901 (59.9) | 299 (61.3) |
| Low-Grade Serous | 18 (3.5) | 12 (2.7) | 60 (4.0) | 11 (2.3) |
| Endometrioid | 35 (6.8) | 47 (10.6) | 119 (7.9) | 41 (8.4) |
| Clear Cell | 16 (3.1) | 18 (4.1) | 125 (8.3) | 36 (7.4) |
| Mucinous | 23 (4.4) | 25 (5.6) | 88 (5.9) | 27 (5.5) |
| Carcinosarcoma | 13 (2.5) | 15 (3.4) | 33 (2.2) | 6 (1.2) |
| Other epithelial | 70 (13.5) | 39 (8.8) | 178 (11.8) | 68 (13.9) |
| Synchronous | 9 (1.7) | 8 (1.8) | 0 (0.0) | 0 (0.0) |
| Stage * | ||||
| Localized | 95 (18.3) | 92 (20.7) | 289 (19.2) | 94 (19.3) |
| Regional | 51 (9.9) | 40 (9.0) | 153 (10.2) | 51 (10.5) |
| Distant | 339 (65.4) | 283 (63.7) | 1042 (69.3) | 333 (68.2) |
| Missing | 33 (6.4) | 29 (6.5) | 20 (1.3) | 10 (2.1) |
| Education | ||||
| HS or less | 794 (46.7) | 381 (29.4) | 707 (18.5) | 136 (13.0) |
| Some college | 407 (23.9) | 365 (28.2) | 918 (24.0) | 250 (23.9) |
| College grad | 317 (18.7) | 288 (22.2) | 1056 (27.6) | 288 (27.5) |
| Grad/prof school | 178 (10.5) | 260 (20.1) | 1148 (30.0) | 373 (35.6) |
| Missing | 4 (0.2) | 1 (0.1) | 0 (0.0) | 0 (0.0) |
| Parity | ||||
| No pregnancies | 253 (14.9) | 213 (16.5) | 831 (21.7) | 222 (21.2) |
| 1–2 pregnancies | 673 (39.6) | 643 (49.7) | 1812 (47.3) | 509 (48.6) |
| ≥3 pregnancies | 772 (45.4) | 436 (33.7) | 1186 (31.0) | 316 (30.2) |
| Missing | 2 (0.1) | 3 (0.2) | 0 (0.0) | 0 (0.0) |
| Oral Contraceptive Duration | ||||
| Never | 595 (35.0) | 380 (29.3) | 1309 (34.2) | 354 (33.8) |
| <5 years | 618 (36.4) | 460 (35.5) | 1287 (33.6) | 390 (37.3) |
| ≥5 years | 458 (26.9) | 445 (34.4) | 1186 (31.0) | 288 (27.5) |
| Missing | 29 (1.7) | 10 (0.8) | 47 (1.2) | 15 (1.4) |
| Body Mass Index, kg/m 2 | ||||
| <25 | 343 (20.2) | 207 (16.0) | 1942 (50.7) | 530 (50.6) |
| 25–29.9 | 492 (28.9) | 401 (31.0) | 1028 (26.9) | 283 (27.0) |
| 30–34.9 | 413 (24.3) | 337 (26.0) | 494 (12.9) | 135 (12.9) |
| ≥35 | 439 (25.8) | 343 (26.5) | 337 (8.8) | 86 (8.2) |
| Missing | 13 (0.8) | 7 (0.5) | 28 (0.7) | 13 (1.2) |
| Smoking Status | ||||
| Never smoker | 908 (53.4) | 743 (57.4) | 1977 (51.6) | 569 (54.4) |
| Former smoker | 460 (27.1) | 366 (28.3) | 1305 (34.1) | 389 (37.2) |
| Current smoker | 331 (19.5) | 185 (14.3) | 545 (14.2) | 89 (8.5) |
| Missing | 1 (0.1) | 1 (0.1) | 2 (0.1) | 0 (0.0) |
| Tubal Ligation Ever | ||||
| No | 1021 (60.1) | 778 (60.1) | 3059 (79.9) | 858 (82.0) |
| Yes | 645 (37.9) | 474 (36.6) | 764 (20.0) | 189 (18.1) |
| Missing | 34 (2.0) | 43 (3.3) | 6 (0.2) | 0 (0.0) |
| First-Degree Family History of Breast or Ovarian Cancer | ||||
| No | 1291 (75.9) | 1009 (77.9) | 3098 (80.9) | 818 (78.1) |
| Yes | 313 (18.4) | 237 (18.3) | 668 (17.5) | 216 (20.6) |
| Missing | 96 (5.7) | 49 (3.8) | 63 (1.7) | 13 (1.2) |
| Menopausal Status | ||||
| Premenopausal | 621 (36.5) | 381 (29.4) | 1196 (31.2) | 217 (20.7) |
| Postmenopausal | 1077 (63.4) | 914 (70.6) | 2633 (68.8) | 830 (79.3) |
| Missing | 2 (0.1) | 0 (0.0) | 0 (0.0) | 0 (0.0) |
| Hormone Therapy Use Duration | ||||
| Never | 1426 (83.9) | 924 (71.4) | 2347 (61.3) | 480 (45.9) |
| <5 years | 159 (9.4) | 210 (16.2) | 602 (15.7) | 186 (17.8) |
| ≥5 years | 100 (5.9) | 156 (12.1) | 815 (21.3) | 359 (34.3) |
| Missing | 15 (0.9) | 5 (0.4) | 65 (1.7) | 22 (2.1) |
| Age at Menarche | ||||
| <11 years | 174 (10.2) | 152 (11.7) | 239 (6.2) | 78 (7.5) |
| 11–12 years | 637 (37.5) | 577 (44.6) | 1560 (40.7) | 447 (42.7) |
| 13–14 years | 596 (35.1) | 432 (33.4) | 1561 (40.8) | 421 (40.2) |
| 15–16 years | 228 (13.4) | 106 (8.2) | 399 (10.4) | 89 (8.5) |
| ≥17 years | 52 (3.1) | 24 (1.9) | 60 (1.6) | 12 (1.2) |
| Missing | 13 (0.8) | 4 (0.3) | 10 (0.3) | 0 (0.0) |
| Premenopausal Hysterectomy | ||||
| No | 1484 (87.3) | 779 (60.2) | 3322 (86.8) | 690 (65.9) |
| Yes | 207 (12.2) | 511 (39.5) | 497 (13.0) | 356 (34.0) |
| Missing | 9 (0.5) | 5 (0.4) | 10 (0.3) | 1 (0.1) |
| History of Infertility † | ||||
| No | 916 (73.3) | 790 (73.1) | 991 (74.7) | 265 (77.9) |
| Yes | 334 (26.7) | 287 (26.6) | 332 (25.0) | 75 (22.1) |
| Missing | 0 (0.0) | 4 (0.4) | 3 (0.2) | 0 (0.0) |
*
Distributions of histotype and stage are only shown for cases
†
History of infertility was not collected for SCCS & LACOCS: 450 Black participants without leiomyomas, 214 Black participants with leiomyomas, 2503 White participants without leiomyomas, 707 White women with leiomyomas.