Table 5.
Overall | High-Grade Serous | Low-Grade Serous | Endometrioid | Clear Cell | Mucinous | p-het | Low-Grade Serous, Endo, & Clear Cell | |
---|---|---|---|---|---|---|---|---|
OR (95% CI) | OR (95% CI) | OR (95% CI) | OR (95% CI) | OR (95% CI) | OR (95% CI) | (between histotypes) | OR (95% CI) | |
All participants (cases/controls) | 2954/4917 | 1814/4917 | 101/4917 | 242/4917 | 195/4917 | 163/4917 | 538/4917 | |
Yes | 1.26 (1.12–1.41) | 1.25 (1.09–1.43) | 0.99 (0.59–1.64) | 1.59 (1.18–2.15) | 1.26 (0.89–1.78) | 1.54 (1.07–2.23) | 0.03 | 1.35 (1.09–1.68) |
Black participants (cases/controls) | 962/2033 | 614/2033 | 30/2033 | 82/2033 | 34/2033 | 48/2033 | 146/2033 | |
Yes | 1.34 (1.11–1.62) | 1.32 (1.06–1.64) | 2.05 (0.83–5.07) | 2.05 (1.24–3.39) | 1.64 (0.77–3.48) | 1.92 (0.99–3.69) | 0.002 | 1.92 (1.31–2.80) |
White participants (cases/controls) | 1992/2884 | 1200/2884 | 71/2884 | 160/2884 | 161/2884 | 115/2884 | 392/2884 | |
Yes | 1.22 (1.05–1.41) | 1.18 (0.99–1.41) | 0.77 (0.39–1.53) | 1.41 (0.95–2.10) | 1.27 (0.84–1.90) | 1.45 (0.91–2.32) | 0.33 | 1.21 (0.92–1.59) |
pheterogeneity by race | 0.54 | 0.69 | 0.22 | 0.21 | 0.39 | 0.52 |
Odd ratios were adjusted for site, age at diagnosis, education, parity, oral contraceptive duration, BMI, smoking status, tubal ligation, family history of breast or ovarian cancer, menopausal status, post-menopausal hormone duration, age at menarche, and premenopausal hysterectomy.