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. Author manuscript; available in PMC: 2024 Sep 1.
Published in final edited form as: Hepatology. 2023 Mar 22;78(3):803–819. doi: 10.1097/HEP.0000000000000354

Figure 2. HNF4α is inactivated in TAA/CLP mice.

Figure 2.

A. HNF4α protein levels in whole liver lysates from mice that were subjected to CLP or sham surgeries. B. HNF4α target gene expression in four groups of mice. C-E. Mice (male and female) were treated with TAA (200mg/L in the drinking water) or received water only and subjected to cecal ligation and puncture (CLP). One week before surgeries mice were treated with AAV.TBG.control or AAV.TBG.Hnf4a vectors at 10^11 gc/mouse. C. INR and PT in these mice one day before or one day after CLP. D-E. Relative gene expression in these mice. F. Correlation between gene expression of Hnf4a and HNF4α target genes in control (water/sham+water/CLP) groups and TAA/CLP group. *, P<0.05, **, P<0.01, ***, P<0.001.