Table 2.

Various rulesets for drug-likeness along with key results Lipinski's rule of five, the Ghose filter, the Veber, Egan, and Muegge rules.

Ruleset	Lipinski	Veber	Ghose	Muegge	Egan
Rule 1	Molecular weight <= 500 Da	Total number of rotatable bonds <= 10	LogP (octanol–water partition coefficient) between −0.4 and + 5.6	Number of hydrogen bond donors <= 5	LogP (octanol–water partition coefficient) between −0.4 and + 5.6
Rule 2	LogP (octanol–water partition coefficient) <= 5	Number of hydrogen bond donors <= 5	Molecular weight <= 480 Da	Molecular weight <= 450 Da	Molecular weight <= 500 Da
Rule 3	Hydrogen bond donors <= 5	Number of hydrogen bond acceptors <= 10	Number of hydrogen bond acceptors <= 10	Molecular refractivity between 40 and 130	Number of hydrogen bond acceptors <= 10
Rule 4	Hydrogen bond acceptors <= 10	Total polar surface area <= 140 Å2	LogP (octanol–water partition coefficient) between −0.4 and + 5.6	N/A	Molecular refractivity between 40 and 130
Rule 5	Number of rotatable bonds <= 10	N/A	Number of rotatable bonds <= 10	N/A	N/A