Fig. 7.

RD2 treatment dependent Aβ oligomer concentration change and its correlation with selective attention outcome. Correlation of changes of CSF Aβ oligomer concentrations with changes of selective attention accuracy. A: Correlation for placebo group. B: Correlation for low dose treated animals with 3 mg/ml RD2. C: Correlation for high dose treated animals with 30 mg/ml RD2. D: Correlation for all groups (placebo, low dose and high dose) together. Changes (Δ) were calculated by subtracting baseline value from three-month treatment value. Correlations of the low dose group, high dose group and all cohorts were significant. No significant correlation was found for the placebo group. Correlation was performed with Spearman (ρ) analysis at alpha level 0.05 with n = 11 to 12.