Table 1.

Pharmacokinetic parameters for RD2 in plasma after single administration of RD2.

Parameter	3 mg/kg (i.v.) Mean ± SD	20 mg/kg (p.o.) Mean ± SD	50 mg/kg (p.o.) Mean ± SD
tmax (h)		2.0 ± 1.6	2.7 ± 2.9
Cmax (ng/ml)	32000 ± 18200	567 ± 427	2380 ± 2280
t1/2 α (h)	0.046	n.c.	n.c.
1% of AUC	3.6	n.c.	n.c.
t1/2 β (h)	2.9	0.56	2.9
2% of AUC	93	78	76
t1/2 γ (h)	71	62	77
a% of AUC	3.4	22	25
AUC0-tlast (h·ng/ml)	29900 ± 4230	3340 ± 1370	19800 ± 19700
AUC0-inf (h·ng/ml)	28600 ± 2540	3890 ± 1120	26000 ± 21900
CLtotal (ml/min·kg)	1.2 ± 0.11
MRT (h)	9.4 ± 1.0	40 ± 15	35 ± 10
Vss (ml/kg)	659 ± 140
F (%)	100	2.0 ± 0.78	5.5 ± 4.5

n.c. denotes not calculable, ¹% of AUC covered by t_{1/2 α,}²% of AUC covered by t_{1/2 β.}

^a% of AUC covered by t_{1/2 γ}.