Table 2.
Pharmacokinetic parameters for RD2 in CSF after single administration.
| Parameter | 3 mg/kg (i.v.) Mean ± SD |
20 mg/kg (p.o.) Mean ± SD |
50 mg/kg (p.o.) Mean ± SD |
|---|---|---|---|
| tmax (h) | 4.2 ± 2.2 | 8.0 ± 8.0 | 8.7 ± 7.8 |
| Cmax (ng/ml) | 71 ± 32 | 13 ± 15 | 21 ± 18 |
| Apparent t1/2 (h)a | 80 ± 5.6 | 190 ± 93 | 119 ± 37 |
| AUC0-tlast (h·ng/ml) | 961 ± 373 | 180 ± 77 | 614 ± 592 |
| AUC0-inf (h·ng/ml) | 990 ± 383 | 242 ± 47 | 659 ± 605 |
| MRT0-inf (h) | 39 ± 4.0 | 155 ± 131 | 97 ± 47 |
| CSF/Plasma AUC0-inf | 0.031 ± 0.011 | 0.066 ± 0.021 | 0.025 ± 0.020 |
a
half-life is estimated from the last 2 time points and thus may not be accurate.