Table 9.

NSAIDs commonly used in pain treatment - O: oral. IV: intravenous. IM: intramuscular. ER: endorectal.

Drug	Pediatric Dosing	Adult dosing	Notes
Paracetamol or Acetaminophen	O. 10-15 mg/kg every 4-5 hours ER: 20-40 mg/kg every 6 hours Or Oral Bolus 20 mg/kg + 15mg/kg every 4 h Bolus 40 mg/kg + 20 mg/kg every 6 hours	O. 325-650 mg every 4-6 hours max 4 gr/day orally	Absence of gastrointestinal and haematological side effects. Antipyretic and analgesic action, not anti-inflammatory. Very low risk of liver toxicity if the daily dose of paracetamol does not exceed 90 mg/kg in healthy children.
Ibuprofen	O. 5-10 mg/kg every 6-8 h	O. 200 mg every 3-4 h	Gastrointestinal and haematological side effects. Anti-inflammatory action.
Naproxen	O. 5 mg/kg every 8-12 h	O. 0.5-1 g/day	Gastrointestinal and haematological side effects. Anti-inflammatory action.
Ketorolac	O. Bolus 1-3 mg/kg every 8 h E.V 0.20 mg/kg/h	O. 10 mg every 4-6 h (max 40 mg/day) EV o IM 10-30 mg every 4-6 hours (max 90 mg/day)	Liver and kidney toxicity.
Acetylsalicylic acid	O. 10-15 mg/kg every 6-8 hours	O. 0.5-1 g every 4-6 hours max 4 g/day	Reye’s syndrome (pre-pubertal children). Gastrointestinal and haematological side effects.