Chen‐Hussey 2013.

Study characteristics
Methods	cRCT Unit of randomization: cluster of houses ICC: not reported Trial duration: 1.5 years (average of 6.4 months follow‐up per cluster)
Participants	Adults or children living in malaria‐endemic regions High risk population (agricultural workers sleeping outdoors) Endemic region for P vivax Participants not screened for hypnozoites
Interventions	Topical repellent: DEET 15% Controls: placebo lotion Co‐interventions: LLINs Treatment arms: Repellent arm: 795 households; 3972 participants Placebo arm: 802 households; 4008 participants
Outcomes	Malaria infection incidence: new Plasmodium spp. infections confirmed through thick or thin blood smears, RDTs, or polymerase chain reaction (PCR) Incidence of recorded adverse events (including skin irritation, local pain, eye irritation, irritation of upper airways, nausea, vomiting, headaches, dizziness or confusion, allergic or anaphylactic reactions, and systemic toxicity) Time to first infection (days) Adherence to regular usage of the intervention (defined based on recommendations provided by researchers to participants of individual trials)
Notes	Conducted in Laos PDR Funded by the Department of Homeland Security, and Fogarty International Center, National Institutes of Health