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. 2023 Aug 21;2023(8):CD015422. doi: 10.1002/14651858.CD015422.pub2

Hill 2007.

Study characteristics
Methods cRCT
Unit of randomization: cluster of houses
ICC: not reported
Trial duration: 7 months (treatment period of 4 months)
Participants Adults or children living in malaria‐endemic regions
Non‐high risk population
Endemic region for P vivax
Participants not screened for hypnozoites
Interventions Topical repellent: PMD: 30% + eucalyptus extract
Controls: placebo lotion (0.1% clove oil used as placebo)
Co‐interventions: LLINs
Treatment arms:
  • Intervention: 424 households (1967 individuals)

  • Control: 436 households (2041 individuals)

Outcomes
  • Malaria infection incidence: new Plasmodium spp. infections confirmed through thick or thin blood smears, RDTs, or polymerase chain reaction (PCR)

  • Incidence of recorded adverse events (including skin irritation, local pain, eye irritation, irritation of upper airways, nausea, vomiting, headaches, dizziness or confusion, allergic or anaphylactic reactions, and systemic toxicity).

  • All‐cause fever

  • Adherence to regular usage of the intervention (defined based on recommendations provided by researchers to participants of individual trials)

Notes Carried out in Bolivia
Funded by Gates Malaria Partnership grant from London School of Hygiene and Tropical Medicine