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. 2023 Aug 21;2023(8):CD015422. doi: 10.1002/14651858.CD015422.pub2

Rowland 2004.

Study characteristics
Methods cRCT
Unit of randomization: cluster of households
ICC: 0.04
Trial duration: 7 months (treatment period of 6 months)
Participants Adults or children living in malaria‐endemic regions
High‐risk population (refugees)
Endemic region for P vivax
Participants not screened for hypnozoites
Interventions Topical repellent: Mosbar soap (20% DEET + 0.5% permethrin)
Controls: placebo lotion
Co‐interventions: none
Treatment arms:
  • Intervention: 67 households (618 participants)

  • Controls: 60 households (530 participants)

Outcomes
  • Incidence of recorded adverse events (including skin irritation, local pain, eye irritation, irritation of upper airways, nausea, vomiting, headaches, dizziness or confusion, allergic or anaphylactic reactions, and systemic toxicity)

  • Malaria prevalence

  • Adherence to regular usage of the intervention (defined based on recommendations provided by researchers to participants of individual trials)

Notes Carried out in a refugee camp with Afghan refugees in malaria‐endemic region of Pakistan
Funded by HealthNet International’s Malaria and Leishmaniasis control and research programme