Table 2.
Cox proportional-hazards models investigating the association between eGFRcr-cys status and incident all-cause dementia by different follow-up periods
| Age and sex adjusted | Fully adjusteda | ||
|---|---|---|---|
| Follow-up period | Cases/Population | HR (95% CI) | HR (95% CI) |
| Complete follow-up | |||
| ≥ 90 | 1,618/64,082 | 1 (Reference) | 1 (Reference) |
| 60–89 | 3,932/129,095 | 1.01 (0.95–1.07) | 1.00 (0.94–1.06) |
| < 60 | 492/9,525 | 1.62 (1.46–1.79) | 1.42 (1.28–1.58) |
| ≤ 5 years | |||
| ≥ 90 | 149/64,085 | 1 (Reference) | 1 (Reference) |
| 60–89 | 361/129,095 | 0.97 (0.80–1.18) | 0.98 (0.80–1.19) |
| < 60 | 51/9,525 | 1.59 (1.15–2.20) | 1.36 (0.98–1.90) |
| > 5 to 10 years | |||
| ≥ 90 | 717/62,661 | 1 (Reference) | 1 (Reference) |
| 60–89 | 1,731/125,140 | 0.99 (0.91–1.08) | 1.00 (0.91–1.09) |
| < 60 | 240/8,792 | 1.71 (1.48–1.99) | 1.53 (1.31–1.78) |
| > 10 years | |||
| ≥ 90 | 752/58,436 | 1 (Reference) | 1 (Reference) |
| 60–89 | 1,840/114,968 | 1.03 (0.94–1.12) | 1.01 (0.93–1.11) |
| < 60 | 201/7,382 | 1.52 (1.30–1.78) | 1.33 (1.13–1.56) |
Abbreviations: CI Confidence Interval, eGFRcr-cys Estimated Glomerular Filtration Rate Creatinine-Cystatin C Equation, HR Hazard Ratio
aModels adjusted for age, sex, ethnicity, Townsend deprivation index, education, household income, country, smoking status, alcohol intake, body mass index, hypertension, diabetes, and APOE status