Figure 2.
CNO enhances operant cocaine self-administration in rats with hM4Di transduction of LHb neurons. (A) Self-administration training: Mean ± SEM number of infusions, active and inactive lever responses during the first 10 days of self-administration training (one 2 h session/d) under a fixed-ratio-1 (FR-1) 20-sec timeout reinforcement schedule (B, D) Mean±SEM number of cocaine infusions self-administered and active lever presses after i.p. injections of vehicle or CNO (1mg/kg) and the corresponding time course represented at 30 minute intervals (n=6) (C, E) Mean±SEM number of cocaine infusions self-administered and active lever presses after i.p. injections of vehicle or CNO (3mg/kg) and the corresponding time course represented at 30 minute intervals (n=7) *Different from vehicle condition, p < 0.05.