Figure 5.

CNO has no effect on operant cocaine self-administration and cocaine-priming and cue-induced reinstatement in rats with no viral vector transduction (A) Self-administration training: Mean ± SEM number of infusions, active and inactive lever responses during 10 days of self-administration training (one 3 h session/d) under a fixed-ratio-1 (FR-1) 20-sec timeout reinforcement schedule (B) Mean±SEM number of cocaine infusions self-administered and active lever presses after i.p. injections of vehicle or CNO (3 mg/kg) (C) Mean±SEM number of active lever presses after pretreatment with CNO (3 mg) or vehicle followed by exposure to a priming injection of cocaine (10 mg) or vehicle (D) Mean±SEM number of active lever presses after pretreatment with CNO (3 mg) or vehicle followed by exposure to contingent tone-light cues or no cues under extinction conditions (n=5).