Figure 7.

CNO decreases cocaine self-administration, food-self administration and cocaine-induced locomotor activity in rats with hM₃D_q transduction of LHb neurons (A) Mean±SEM number of cocaine infusions self-administered after i.p. injections of vehicle or CNO (1 and 3 mg/kg) (n=6) (B) Mean±SEM number of food pellets self-administered after i.p. injections of vehicle or CNO (1 and 3 mg/kg) (n=9) (C) Mean±SEM of the total number of beam breaks over 1h in rats pretreated with CNO (0.01, 0.1, 1 or 3 mg) or vehicle twenty minutes prior to a single injection of cocaine (10 mg) (n=4) (D) Mean±SEM of latency of the rat to fall of the rotarod after i.p. injections of vehicle or CNO (1 and 3 mg/kg) (n=5)