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. 2023 Aug 18;9(3):e003160. doi: 10.1136/rmdopen-2023-003160

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© Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

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Adjusted drug retention due to (A) ineffectiveness and (B) toxic adverse events. The adjusted confounders included baseline age, sex, disease duration, Clinical Disease Activity Index (CDAI), concomitant use of glucocorticoids, methotrexate and other conventional synthetic disease-modifying antirheumatic drugs (csDMARDs), number of switched biological DMARDs or JAKis and prior use of TNFi, aIL-6R, CTLA4-Ig and JAKi. aIL-6R, anti-IL-6 receptor antibodies; CTLA4-Ig, cytotoxic T lymphocyte-associated antigen-4-Ig; JAKi, Janus kinase inhibitors; TNFi, tumour necrosis factor inhibitors.