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. 2023 Aug 18;11(8):e007080. doi: 10.1136/jitc-2023-007080

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© Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.

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LMWH had neither cytotoxicity to tumor cells nor ability to activate lymphocytes. (A) Effects of different concentrations of LMWH on the survival rate of tumor cells. (B) Cytotoxic effect of LMWH combined with or without lymphocytes on tumor cells. (C) Killing effect of LMWH combined with activated/non-activated lymphocytes on tumor cells. (D) Cytotoxic effect of activated/non-activated lymphocytes on tumor cells. (E) Quantitative analysis of CD69 and PD-1 expression on CD8+T cells and CD4+T cells of Balb/c mouse spleen lymphocytes treated with LMWH, concanavalin A, or both for 24 hours. LMWH, low molecular weight heparin.