Table 2.

Pharmacological parameters for 5Me3F4AP, 3F4AP, 4AP and 3Me4AP.

Drug	pKa	logD (pH 7.4)	Pe (nm/s)
5Me3F4AP	7.46 ± 0.01	0.664 ± 0.005	43.3 ± 0.5
4AP	9.19 ± 0.03	−1.478 ± 0.014a	2.36 ± 0.03b
3F4AP	7.37 ± 0.07	0.414 ± 0.002a	13.6 ± 0.5c
3Me4AP	9.82 ± 0.06a	−1.232 ± 0.008a	--

logD: experimental partition coefficient octanol: water at pH 7.4 (n =4).

pK_a: experimental titration coefficient at room temperature (n =3).

P_e: permeability rate across the artificial membrane (n = 2).

^apreviously reported data using the equipment and protocol (Rodriguez-Rangel et al., 2020).

^bpreviously reported data (Brugarolas et al., 2018b).

^cresult obtained during the present study, a value of 15.6 ± 0.6 nm/s was previously reported (Brugarolas et al., 2018b).